1601
- Births: Ana Maria Mauricia (September 22), Louis XIII (September 27)
1603
- March 23. Tokugawa Ieyasu (60) is formally named Shogun by Emperor Go-Yozei of Japan.1
- March 24. Queen Elizabeth of England (69) dies.2
- April O'Neil (23/1990) is mystically transported to Japan in this era. She is followed by the Turtles Leonardo, Michelangelo, Donatello, and Raphael (all 15/1990), who rescue her and return to the future.3
1605
- Miguel de Cervantes first publishes the novel Don Quixote, a novelization of the adventures of the eponymous "knight".
Shogun Tokugawa Ieyasu abdicates as formal Shogun, though he does not actually relinquish power.
Nur-ud-din Muhammad Jahangir Badshah Ghazi (formerly Salim) accedes as Emperor of the Mughal Empire.
1606
- William Shakespeare (42) completes the play Macbeth, loosely based the life of the Scottish king.4
July 15. Rembrandt Harmenzsoon van Rijn is born in Leiden, Holland, Dutch Republic.
1607
- April 26. The Virginia Company vessels Susan Constant, Godspeed, and Discovery make landfall on the east coast of North America.
Chief Powhatan's daughter Pocahontas helps stop a war between the English settlers (led by Captain John Radcliffe) and the Powhatan tribe.
May 24. The English Virginia Company founds Fort Jamestown.
1608
August. On Mobius, the home of Lord Mifune is attacked by ninja assassins under the command of rival lord Hikiji. Mifune's family is slaughtered, and he himself is beheaded. Mifune's samurai, Miyamoto Usagi (22), is scarred while battling Hijiki, but he manages to escape and bury his master's head. From then he becomes a ronin, and seeks to avenge his master's murder.
1609
September 17. Rabbi Judah Loew ben Bezalel (82) dies.
November 13. Miyamoto Usagi (23) is briefly transported through time to Earth in 1992.
1610
May 14. Louis XIII ascends to the kingship of France after the assassination of his father. Still a child, his mother Marie de Medici rules as regent for three years.
