First Appearances S
  1. Saavik. The character first appears in the film Star Trek II: The Wrath of Khan (1982).
  2. Salem Saberhagen. The character first appears in the comic book Archie's Mad House #22 (1962). His surname is established in ???
  3. Silver Sablinova/Silver Sable. The character first appears in the comic book The Amazing Spider-Man #265 (1985).
  4. Sadann/Magic Mirror. The character first appears, outside of oral folklore, in the short story "Snow White" in the anthology Grimm's Fairy Tales (1812). His name is arbitrary.
  5. Cheren Sagamoto. The character first appears in the video games Pokémon Black and White Versions (2010). His surname is arbitrary.
  6. Vic Sage/Charles Victor Szasz/The Question. The character first appears in the comic book Blue Beetle #1 (1967).
  7. Sain of Lycia. The character first appears in the video game Fire Emblem: The Blazing Blade (2003).
  8. Clair Saito. The character first appears, with her Japanese name of Ibuki, in the video games Pokémon Gold and Silver Versions (1999). Her English name is established in the North American release (2000). Her surname is arbitrary.
  9. Saizo of Hoshido. The character first appears in the video game Fire Emblem: If (2015).
  10. Sakura of Hoshido. The character first appears in the video game Fire Emblem: If (2015).
  11. Lisbeth Salander. The character first appears in the novel The Girl with the Dragon Tattoo (2005).
  12. Theodore "Ted" Sallis/Man-Thing. The character first appears in the comic book Savage Tales #1 (1971).
  13. Vienna Salvatori. The character first appears in the Doctor Who audio drama The Shadow Heart (2012).
  14. Sam (canine P.I.). The character first appears in the comic book Sam & Max: Freelance Police (1987).
  15. Parvati Samavedam/Inque. The character first appears in the Batman Beyond animated series episode "Black Out" (1999). Her real name is arbitrary.
  16. Riki Samejima. The character first appears in the arcade game Nekketsu Koha Kunio-kun (1986).
  17. Eddy Sampson. The character first appears in the Ed, Edd n Eddy animated series premiere episode "The Ed-Touchables" (1999). His surname is arbitrary.
  18. Gregor Samsa. The character first appears in the short story "The Metamorphosis" (1915).
  19. Brock Samson. The character first appears in the The Venture Bros. animated series pilot episode "The Terrible Secret of Turtle Bay" (2003).
  20. Samuel (Hebrew judge). The character first appears, narratively, in the First Book of Samuel, in the Tanakh/Bible, written in antiquity.
  21. Samuel/Smoke Monster. The character first appears as a Smoke Monster in the Lost television series pilot episode "Pilot, Part 1" (2004). His name is arbitrary.
  22. Kuki Sanban/Numbuh 3. The character first appears in the Codename: Kids Next Door animated series pilot short "No P in the OOL" (2004).
  23. Marcelino "Rembrandt" Sanchez. The character first appears, as Rembrandt, in the film The Warriors (1979). His real name is arbitrary.
  24. Rick Sanchez. The character first appears in the Rick and Morty animated series pilot episode (2013).
  25. Gregory Sanders/Vigilante. The character first appears in the comic book Action Comics #42 (1941).
  26. James "Jim" Sanders/Speed Demon/Whizzer. The character first appears in the comic book Avengers #70 (1969). He first appears as Speed Demon in The Amazing Spider-Man #222 (1981).
  27. Steven "Steve" Sanders. The character first appears in the Beverly Hills 90210 television series pilot episode "Class of Beverly Hills" (1990).
  28. Carmen Sandiego. The character first appears in the computer game Where in the World Is Carmen Sandiego? (1985).
  29. Cassandra "Cassie" Sandsmark/Wonder Girl. The character first appears in the comic book Wonder Woman #105 (1996). She adopts the Wonder Girl identity in Wonder Woman #111 (1996).
  30. Sandy (Annie's dog). The character first appears in the Little Orphan Annie comic strip (1925).
  31. Sans. The character first appears in the video game Undertale (2015).
  32. Santa Claus/St. Nicholas/Kris Kringle/Father Christmas/Pere Noel. The character has origins in the character of Odin (see above) and the historical figure of St. Nicholas of Myra. The character has many origins and is a combination of such. The English idea of Father Christmas derives from the 17th century as a personification of Christmas cheer. The name Santa Claus is a corruption of Sinterklaas (itself a corruption of St. Nicholas), first used c. 1773.
  33. Santa Claus (robot). The character first appears in the Futurama animated series episode "Xmas Story" (1999).
  34. James "Jimmy" Santini/Batwing. The character first appears in the comic book Untold Tales of Spider-Man #2 (1995).
  35. Miguel Santos/Living Lightning. The character first appears in the comic book Avengers West Coast #63 (1990).
  36. Genma Saotome. The character first appears in the Ranma 1/2 manga Chapter 1: "Here's Ranma" (1987).
  37. Ranma Saotome. The character first appears in the Ranma 1/2 manga Chapter 1: "Here's Ranma" (1987).
  38. Sarah/Sarai. The character first appears, narratively, in the Book of Genesis in the Torah, written in antiquity.
  39. Daisy Sarasa. The character first appears in the video game Super Mario Land (1989). Her surname is arbitrary, taken from the kingdom she hails from, Sarasaland.
  40. Kazran Sardick. The character first appears in the Doctor Who television series episode "A Christmas Carol" (2010).
  41. Sarek. The character first appears in the Star Trek television series episode "Journey to Babel" (1967).
  42. Saria/Famine. The character first appears in the video game The Legend of Zelda: Ocarina of Time (1998). The Famine code-name is apocryphal.
  43. Sarjenka. The character first appears in the Star Trek: The Next Generation television series episode "Pen Pals" (1989).
  44. Ophelia Sarkissian/Viper/Madame Hydra. The character first appears, as Madame Hydra, in the comic book Captain America #110 (1969). She first appears as Viper in Captain America #180 (1974). Her real name is revealed in The Official Handbook of the Marvel Universe A-Z #12 (2010).
  45. Saru. The character first appears in the Star Trek: Discovery television series premiere episode "The Vulcan Hello" (2017).
  46. Saruman. The character first appears in the novel The Lord of the Rings: The Fellowship of the Ring (1954).
  47. Sarya/Empress/Emerald Empress. The character first appears in the comic Adventure Comics #352 (1967). The incarnation primarily used in this timeline first appears in Legion of Super-Heroes #78 (1996).
  48. Cissy Sasuka. The character first appears, as Atsumi, in the Pokémon anime episode "Orange League! [Mikan] Gym!" (1999). She receives the dub name Cissy in the adaptation of the episode, "Fit to Be Tide" (2000). Her surname is arbitrary.
  49. Hoshi Sato. The character first appears in the Enterprise television series pilot episode "Broken Bow" (2001).
  50. Kohta Sato. The character first appears in the My Balls manga initial chapter "First Ball: That, Already?!" (2006).
  51. Toshiko "Tosh" Sato. The character first appears in the Doctor Who television series episode "Aliens of London" (2005). Her given name is established in the Torchwood television series premiere episode "Everything Changes" (2006).
  52. Ellen "Ellie" Sattler Dengler. The character first appears in the novel Jurassic Park (1990).
  53. Azra Saugin. The character first appears in the comic book Legion of Super-Heroes Annual #6 (1995).
  54. Thanot "Than" Saugin/Bio/Revelation. The character first appears in the comic book Legion of Super-Heroes #66 (1995). The Bio and Revelation code-names are apocryphal.
  55. Zoe Saugin/Kinetix/Genesis. The character first appears in the comic book Legion of Super-Heroes #66 (1995). The later Genesis code-name is apocryphal.
  56. Kendra Saunders/Hawkgirl. The character first appears in the comic book JSA Secret Files and Origins #1 (1999).
  57. Sauron/Necromancer. The character first appears (sort of) in the The Lord of the Rings novel The Fellowship of the Ring (1954).
  58. Scandal Savage. The character first appears in the comic book Villains United #1 (2005).
  59. Vandal Savage/Vandar Adg. The character first appears in the comic book Green Lantern #10 (1944).
  60. Edie Sawyer/U-Go Girl. The character first appears in the comic book X-Force #116 (2001).
  61. Margaret "Maggie" Sawyer. The character first appears in the comic book Superman #4 (1987).
  62. Thomas "Tom" Sawyer. The character first appears in the novel The Adventures of Tom Sawyer (1876).
  63. Sayd/Guardian Angel. The character first appears in the comic book Green Lantern: Sinestro Corps Special #1 (2007). The Guardian Angel identity is apocryphal.
  64. Say'ri. The character first appears in the video game Fire Emblem: Awakening (2012).
  65. Scar (lion). The character first appears in the animated film The Lion King (1994).
  66. Scarecrow of Oz. The character first appears in the novel The Wonderful Wizard of Oz (1900).
  67. Kimberly "Kimmy" Schmidt. The character first appears in the online television series Unbreakable Kimmy Schmidt debut episode "Kimmy Goes Outside!" (2015).
  68. Rol Purtha Schnappin/Dream Boy. The character first appears in the comic book Supergirl and the Legion of Super-Heroes #18 (2006). His surname here is arbitrary.
  69. Thomas Hector "Tommy" "Hex" Schofield/Hector Thomas. The character first appears in the Doctor Who audio drama The Harvest (2004). He first appears as Hector Thomas in the audio drama Afterlife (2013).
  70. Winslow Schott/Toyman. The character first appears in the comic book Action Comics #64 (1943).
  71. Dwight Schrute III. The character first appears in the pilot episode of the The Office television series (2005).
  72. Charmaine "Schultzy" Schultz. The character apparently first appears in the The Bob Cummings Show episode "Hiring a Receptionist" (1955).
  73. Hans Schultz. The character first appears in the Hogan's Heroes television series pilot episode "The Informer" (1965).
  74. Herman Schultz/Shocker. The character first appears in the comic book The Amazing Spider-Man #46 (1967).
  75. Samuel "Yosemite Sam" Schultz. The character first appears in the Merrie Melodies animated short film Hare Trigger (1945).
  76. Schroeder Schulz. The character first appears in a Peanuts comic strip in 1951. His surname is arbitrary.
  77. Edward Scissorhands. The character first appears in the film Edward Scissorhands (1990).
  78. Scooby-Doo. The character first appears in the Scooby-Doo, Where Are You? animated series premiere episode "What a Night for a Knight" (1969).
  79. Scooby-Dum. The character first appears in the The Scooby-Doo/Dynomutt Hour animated series episode "The Gruesome Game of the Gator Ghoul" (1976).
  80. Scorponok/Strafenok. The character first appears in the Beast Wars: Transformers animated series premiere episode "Beast Wars (Part 1)" (1996). The earlier name is arbitrary.
  81. Alan Scott/Green Lantern/Sentinel. The character first appears in the comic book All-American Comics #16 (1940). He first appears as Sentinel in ???
  82. Bryan "Kidd" Scott. The character first appears in the Kidd Video live-action/animated television series premiere episode "To Beat the Band" (1984). His real name is arbitrary.
  83. Scott Free/Mister Miracle. The character first appears in the comic book Mister Miracle #1 (1971).
  84. Jason Scott/Red Ranger. The character first appears in the Mighty Morphin' Power Rangers premiere episode "The Day of the Dumpster" (1993).
  85. Michael Scott. The character first appears in the pilot episode of the The Office television series (2005).
  86. Montgomery "Scotty" Scott. The character first appears in the Star Trek television series second pilot episode "Where No Man Has Gone Before" (1966).
  87. Wilhelmina "Willie" Scott. The character first appears in the film Indiana Jones and the Temple of Doom (1984).
  88. Scrappy-Doo. The character first appears in the Scooby-Doo and Scrappy-Doo animated series episode "The Scarab Lives!" (1979).
  89. Scratch (Badnik). The character first appears in the Adventures of Sonic the Hedgehog animated series debut episode "Super Special Sonic Search & Smash Squad" (1993).
  90. Otto Scratchansniff. The character first appears in the Animaniacs animated series segment "De-Zanitized" (1993).
  91. Ebenezer Scrooge. The character first appears in the novella A Christmas Carol (1843).
  92. Dana Scully. The character first appears in the pilot episode of the television series The X-Files (1992).
  93. Scuttle (seagull). The character first appears in the animated film The Little Mermaid (1989).
  94. Jonathan Livingston Seagull. The character first appears in the story Jonathan Livingston Seagull (1970).
  95. Cole Sear. The character first appears in the film The Sixth Sense (1999).
  96. Benjamin "Ben" Seaver. The character first appears in the pilot episode of the television series Growing Pains (1985).
  97. Sebastian (crab). The character first appears in the animated film The Little Mermaid (1989).
  98. Judy Sebben/Birdgirl. The character first appears in the Harvey Birdman, Attorney at Law animated series episode "The Bird Girl of Guantanamole" (2005).
  99. Phil Ken Sebben/Falcon 7. The character first appears, as Falcon 7, in the animated series Birdman and the Galaxy Trio segment "The Menace of Dr. Millennium" (1967). His real name is established in the Harvey Birdman, Attorney at Law animated series episode "Death by Chocolate" (2002).
  100. Sefako/the Adversary. The character first appears in the comic book Uncanny X-Men #188 (1984). The Sefako name is first used in Black Panther #171 (2018).
  101. Seg-El. The character first appears as Jor-El (father of Jor-El) in the comic book Superman #103 (1956). He is first named Seyg-El in World of Krypton #3 (1988). The spelling Seg-El is first used in the Krypton television series pilot episode (2018).
  102. Jerome "Jerry" Seinfeld. The fictionalized version of a real person first appears in the pilot episode of the television series The Seinfeld Chronicles (later Seinfeld) (1989).
  103. Drura Sehpt/Contagion/Infectious Lass. The character first appears in the comic book Superboy #201 (1974). The version featured largely in this timeline first appears in The Legion #25 (2003). The later Contagion code-name is apocryphal.
  104. Sela (Romulan). The character first appears in the Star Trek: The Next Generation episode "The Mind's Eye" (1991).
  105. Selar. The character first appears in the Star Trek: The Next Generation television series episode "The Schizoid Man" (1989).
  106. Selene (immortal). The character first appears in the comic book New Mutants #9 (1983).
  107. Selene (vampire). The character first appears in the film Underworld (2003).
  108. Seline (Weird Sister). The character first appears in the history Holinshed's Chronicles (1587). The character receives a name, Seline, in the Gargoyles animated series episode "City of Stone Part One" (1995).
  109. Selkie (daughter of Kaden). The character first appears, as Kinu, in the video game Fire Emblem: If (2015). She is renamed Selkie for the English release of Fire Emblem: Fates (2016).
  110. Claire Selton/Volcana. The character first appears in the Superman: The Animated Series animated series episode "Where There's Smoke" (1998).
  111. Tsutomu Senkawa. The character first appears in the manga Tetsuwan Birdy in Shonen Sunday Super magazine (1985).
  112. Suvik Senyaka. The character first appears in the comic book Uncanny X-Men #300 (1993).
  113. Sephiroth. The character first appears in the video game Final Fantasy VII (1997).
  114. Serenity (Mylenyal). The character first appears in the Pretty Soldier Sailor Moon manga chapter "Act 10 — Moon" (1993?)
  115. Serra of Lycia. The character first appears in the video game Fire Emblem: The Blazing Blade (2003).
  116. Inara Serra. The character first appears in the Firefly television series pilot episode "Serenity" (2002).
  117. Serifan. The character first appears in the comic book Forever People #1 (1971).
  118. Mark Sestero. The character first appears in the film The Room (2003). His surname is arbitrary.
  119. Tom Servo/Beeper. The character first appears in the Mystery Science Theater 3000 initial incarnation first episode Invaders from the Deep (1988).
  120. Irayla Seska. The character first appears in the Star Trek: Voyager episode "Parallax" (1995). Her given name is arbitrary.
  121. Set (god). The character first appears, in hieroglyphs, in ancient writings dating back to Pyramid texts (c. 3900 BCE).
  122. Set (Elder God). The character first appears in the short story "The Phoenix on the Sword", published in Weird Tales (1932).
  123. Setsuna of Hoshido. The character first appears in the video game Fire Emblem: If (2015).
  124. Anton Sevarius. The character first appears in the Gargoyles animated series episode "Metamorphosis" (1995).
  125. Gary Seven. The character first appears in the Star Trek television series episode "Assignment: Earth" (1968).
  126. Severa/Selena. The character first appears, as Serena, in the video game Fire Emblem: Awakening (2012). She is renamed Severa for the English release. She takes the Selena identity in Fire Emblem: Fates (2015).
  127. Alvin Seville. The character first appears in the novelty record "The Chipmunk Song" (1958).
  128. David "Dave" Seville. Originally the stage-name of real person Ross Bagdasarian, the fictionalized version first appears in the novelty record "The Chipmunk Song" (1958).
  129. Simon Seville. The character first appears in the novelty record "The Chipmunk Song" (1958).
  130. Theodore Seville. The character first appears in the novelty record "The Chipmunk Song" (1958).
  131. Timothy Seymour/Mutagen Man/Pulverizer. The character first appears in the Teenage Mutant Ninja Turtles animated series episode "Enter: Mutagen Man" (1991). His given name and Pulverizer identity is established in a later series of the same name in the episode "The Pulverizer" (2013). His surname is arbitrary.
  132. Neal Shaara/Thunderbird. The character first appears in the comic book X-Men #100 (2000).
  133. Ted Shackleford. The character first appears, as simply the Man with the Yellow Hat, in the children's book Curious George (1941). His name is established in the animated film Curious George (2006).
  134. Keith Shadis. The character first appears in the Attack on Titan manga initial chapter "To You, 2000 Years from Now" (2009).
  135. Shadow the Hedgehog. The character first appears in the video game Sonic Adventure 2 (2001).
  136. Shadow King/Amahl Farouk. Amahl Farouk first appears in the comic book X-Men #117 (1979). His surviving essence is first identified as the Shadow King in Uncanny X-Men #265 (1990).
  137. Shadowspawn (Umbreon). The character first appears, as an Eevee, in the Pokémon anime series episode "Rival Showdown! [Ash] vs. [Gary]!" (1999). It first appears as an Umbreon in the episode "[Umbreon]! Battle During a Dark Night!" (2000). Its name is apocryphal.
  138. John Shaft. The character first appears in the novel Shaft (1970).
  139. Davan Shakari/Eric the Red. The character first appears in the comic book X-Men #97 (1976). His real name is revealed in X-Men #105 (1977).
  140. Master Shake. The character first appears in the Aqua Teen Hunger Force animated series premiere episode "Rabbot" (2000).
  141. Richard Kent Shakespeare/The Bard. The character first appears in the comic book Legion of Super-Heroes #12 (1990). The version in this timeline first appears in The Legion #25 (2003). The The Bard code-name is apocryphal.
  142. Shamhat. The character first appears outside oral tradition in the Epic of Gilgamesh poem (c. 1750 BCE).
  143. Shampoo. The character first appears in the Ranma 1/2 manga Chapter 30: "The Waters of Love" (1988). Her name is established in Chapter 31: "Kiss of Death" (1988).
  144. Shan Yu. The character first appears in the animated feature film Mulan (1998).
  145. Shanna of Ilia. The character first appears in the video game Fire Emblem: The Binding Blade (2002).
  146. Karima Shapandar/Omega Sentinel. The character first appears in the comic book X-Men Unlimited #27 (2000).
  147. Shaper of Worlds. The character first appears in the comic book The Incredible Hulk #155 (1972).
  148. Pava Ek'Noor sh'Aqabaa. The character first appears in the comic book Star Trek: Starfleet Academy #1 (1996). The sh' prefix for her clan name is established in the Star Trek: Titan novel Taking Wing (2005).
  149. Dave Shar/Rash. The character first appears in the video game Battletoads (1991).
  150. Sharena of Askr. The character first appears in the mobile game Fire Emblem Heroes (2017).
  151. Sharkboy. The character first appears in the film The Adventures of Sharkboy and Lavagirl (2005).
  152. Brandon Sharpe/Striker. The character first appears in the comic book Avengers Academy #1 (2010).
  153. Shatterstar/Gaveedra-7. The character first appears in the comic book New Mutants #99 (1991). The Gaveedra-7 name is revealed in X-Force #38 (1994).
  154. Shaun the Sheep. The character first appears in the animated short film A Close Shave (1995).
  155. Elizabeth "Liz" Shaw. The character first appears in the Doctor Who television series episode "Spearhead from Space, Episode 1" (1970).
  156. Emily Cooper Shaw. The character first appears in the Doctor Who: The Companion Chronicles audio drama The Last Post (2012). Her maiden name is arbitrary.
  157. Korrina Shaw. The character first appears in the video games Pokémon X and Y Versions (2013). Her surname is arbitrary.
  158. Sebastian Shaw/Black King. The character first appears, unidentified, in the comic book X-Men #129 (1980).
  159. Shinobi Shaw. The character first appears in the comic book X-Factor #67 (1991).
  160. Shaymin. The character first appears in the video games Pokémon Diamond and Pearl Versions (2006).
  161. Shazam/Jebediah/The Wizard. The character first appears in the comic book Whiz Comics #2 (1940).
  162. Shazzan. The character first appears in the Shazzan animated series premiere episode "The Living Island" (1967).
  163. Elizabeth Shelby. The character first appears in the Star Trek: The Next Generation television series episode "The Best of Both Worlds, Part I" (1990). Her given name is established in the novel Vendetta (1991).
  164. Tom Shelvocke/Ancient Mariner. The character first appears, as the Ancient Mariner, in the poem The Rime of the Ancient Marinere (1798). The name Tom Shelvocke comes from the The Keys to the Kingdom novel Grim Tuesday (2004).
  165. Jack Shephard. The character first appears in the Lost television series pilot episode "Pilot: Part 1" (2004). His surname is established in ???
  166. Derek Shepherd. The character first appears in the Grey's Anatomy television series pilot episode "A Hard Day's Night" (2005).
  167. Thomas "Tommy" Shepherd/Thomas Maximoff/Speed. The character first appears (is born in), as Thomas Maximoff, in Vision and the Scarlet Witch #12 (1986). The Tommy Shepherd incarnation first appears in Young Avengers #10, and adopts the Speed code-name in Young Avengers #12 (2006).
  168. Shere Khan. The character first appears in the short story "Mowgli's Brothers" (1894), later collected in The Jungle Book (1895).
  169. Jay Sherman. The character first appears in the The Critic animated series premiere episode (1994).
  170. Shigure (son of Azura). The character first appears in the video game Fire Emblem: If (2015).
  171. Corky Sherwood. The character first appears in the Murphy Brown television series pilot episode "Respect" (1988).
  172. Charles "Chuck" Shijima. The character first appears in the video games Pokémon Gold and Silver Versions (1999). His English nickname is established in the North American release (2000). His full given name is arbitrary.
  173. Shikari Lonestar/Pathfinder. The character first appears in the comic book Legion Lost #1 (2000). The Pathfinder code-name is apocryphal. Shikari's likely antecedent, Dawnstar, first appears in Superboy and the Legion of Super-Heroes #226 (1977).
  174. Tetsuo Shima. The character first appears in the Akira manga, published in Young Magazine (c. 1982).
  175. Michi "Trixie" Shimura. The character first appears in the first chapter of Mach GoGoGo manga published in Shonen Book magazine (1966). Her nickname, Trixie, is established in the Speed Racer anime adaptation's premiere episode "The Great Plan, Episode 1" (1967).
  176. Mai Shiranui. The character first appears in the arcade video game Legend of the Hungry Wolf 2: The New Battle (1992).
  177. Shiro (son of Ryoma). The character first appears, as Shinonome, in the video game Fire Emblem: If (2015). He receives the name Shiro in the English release of Fire Emblem: Fates (2016).
  178. Shirobon/Bomberman. The character first appears in the video game Bomberman (1983).
  179. Takashi "Shiro" Shirogane/Black Paladin. The character first appears in the Beast King GoLion anime premiere episode "Escape from Slave Castle" (1981). The Shiro nickname and Black Paladin identity are first used in the adaptation Voltron: Legendary Defender premiere episode "The Rise of Voltron" (2016).
  180. Johann Shmidt/Red Skull. The character first appears in the comic book Captain America Comics #1 (1941). His real name is established in Captain America #298 (1984).
  181. Arnold Shortman. The character first appears in the stop motion-animated short film Arnold Escapes from Church, featured on the television series Pee-Wee's Playhouse (1988). His surname, long implied, is confirmed by the creators.
  182. Thy'lek Shran/Hravishran th'Zoarhi. The character first appears, as simply Shran, in the Enterprise television series episode "The Andorian Incident" (2001). His first name is established ???. His imperial name is established in the Star Trek: Enterprise novel The Good that Men Do (2007).
  183. Shrek. The character first appears in the children's book Shrek! (1990).
  184. Shreshtimbolagziko!!t'entu/Shresht. The character first appears in the Star Trek: Enterprise television series episode "The Xindi" (2003). Its short-form/birth name is established in the novelization The Expanse (2003). Its full name is arbitrary.
  185. Gerard Shugel/Ultra-Humanite. The character first appears in the comic book Action Comics #13 (1939). His real name is revealed in Power Girl #2 (2009).
  186. Shulk. The character first appears in the video game Xenoblade (2010).
  187. Gordon Shumway/ALF. The character first appears in the ALF television series pilot episode "A.L.F." (1986). His surname is established in ???
  188. Kevin Sidney/Changeling/Morph. The character first appears in the comic book X-Men #35 (1967). He appears as Morph in the X-Men animated series premiere episode "Night of the Sentinels (Part 1)" (1992). His real name is established ???
  189. Siegbert (son of Xander). The character first appears in the video game Fire Emblem: If (2015).
  190. Sigmund Völsungson/Siegmund. The character first appears, perhaps, outside oral tradition, in the Völsunga saga (c. 1275).
  191. Signy Völsungsdottir/Sieglinde. The character first appears, perhaps, outside oral tradition, in the Völsunga saga (c. 1275).
  192. Sigurd of Grannvale. The character first appears in the video game Fire Emblem: Genealogy of the Holy War (1996).
  193. Sigurd Sigmundson/Siegfried. The character first appears, perhaps, outside oral tradition, in the Völsunga saga (c. 1275).
  194. Sil (Mentor). The character first appears in the Doctor Who television series episode "Vengeance on Varos, Part One" (1985).
  195. Silas of Nohr. The character first appears in the video game Fire Emblem: If (2015).
  196. Silque of Zofia. The character first appears in the video game Fire Emblem: Gaiden (1992).
  197. Silver the Hedgehog. The character first appears in the video game Sonic the Hedgehog (2006).
  198. "Long" John Silver. The character first appears in the serialized story "Treasure Island, or the Mutiny of the Hispaniola", originally published in Young Folks magazine (1881). The Ursid version first appears in the animated feature film Treasure Planet (2002).
  199. Jody Silver. The character first appears in the The Puzzle Place television series debut episode "Tippy Woo" (1995).
  200. Miles Silverberg. The character first appears in the Murphy Brown television series pilot episode "Respect" (1988).
  201. Silverbolt/Jetstorm. The character first appears in the Beast Wars: Transformers animated series episode "Coming of the Fuzors (Part 1)" (1997). He first appears as Jetstorm in the Beast Machines: Transformers animated series episode "Fires of the Past" (1999).
  202. Simba (lion). The character first appears in the animated film The Lion King (1994).
  203. Phigus Simenon. The character first appears in the Star Trek: The Next Generation novel Reunion (1991).
  204. Albert "Al" Simmons/Spawn. The character first appears in the comic book Spawn #1 (1992).
  205. Jemma Simmons. The character first appears in the pilot episode of the Marvel's Agents of S.H.I.E.L.D. television series (2013).
  206. Mabel "Madea" Simmons. The character first appears in the stage play I Can Do Bad All by Myself (1999).
  207. Audrid Simod Dax. The character first appears in the Star Trek: Deep Space Nine short story anthology The Lives of Dax story "Sins of the Mother" (1999). Her surname is arbitrary.
  208. Andrew Jackson "A.J." Simon. The character first appears in the Simon & Simon television series pilot episode (1981).
  209. Lorna Simon. The character first appears in the Star Trek novel Best Destiny (1992).
  210. Richard "Rick" Simon. The character first appears in the Simon & Simon television series pilot episode (1981).
  211. Abraham "Abe" Simpson. The character appears, as Grandpa Simpson, in the animated short "Grandpa and the Kids" on the The Tracey Ullman Show television series (1988). His given name is established in ???
  212. Bartholomew "Bart" Simpson. The character first appears in the animated short segment "Good Night" on The Tracey Ullman Show television series (1987).
  213. Homer Simpson. The character first appears in the animated short segment "Good Night" on The Tracey Ullman Show television series (1987).
  214. Lisa Simpson. The character first appears in the animated short segment "Good Night" on The Tracey Ullman Show television series (1987).
  215. Margaret "Maggie" Simpson. The character first appears in the animated short segment "Good Night" on The Tracey Ullman Show television series (1987).
  216. Marjorie "Marge" Bouvier Simpson. The character first appears in the animated short segment "Good Night" on The Tracey Ullman Show television series (1987).
  217. Penelope Mona Olsen Simpson. The character first appears in the The Simpsons animated series episode "Oh Brother, Where Art Thou?" (1991).
  218. Baby Sinclair. The character first appears (is born) in the Dinosaurs television series pilot episode "The Mighty Megalosaurus" (1991). He is formally named Baby in the episode "And the Winner Is…" (1992).
  219. Charlene Sinclair. The character first appears in the Dinosaurs television series pilot episode "The Mighty Megalosaurus" (1991).
  220. Earl Sinclair. The character first appears in the Dinosaurs television series pilot episode "The Mighty Megalosaurus" (1991).
  221. Frances "Fran" Phillips Sinclair. The character first appears in the Dinosaurs television series pilot episode "The Mighty Megalosaurus" (1991).
  222. Isabelle "Izzy" Sinclair. The character first appears in the Doctor Who comic strip story "Endgame", beginning in Doctor Who Magazine #244 (1996).
  223. Rahne Sinclair/Wolfsbane. The character first appears in the comic book Marvel Graphic Novel #4 (1982).
  224. Robert "Robbie" Sinclair. The character first appears in the Dinosaurs television series pilot episode "The Mighty Megalosaurus" (1991).
  225. Damara Sinclaire/Allure. The character first appears in the comic book Relative Heroes #1 (2000).
  226. Thaal Sinestro. The character first appears in the comic book Green Lantern #7 (1961).
  227. Sinfjötli Sigmundson. The character first appears, perhaps, outside oral tradition, in the Völsunga saga (c. 1275).
  228. Hadji Singh. The character first appears in the Jonny Quest animated series episode "Arctic Splashdown" (1964). His surname is revealed in the Real Adventures of Jonny Quest (1996).
  229. Khan Singh. The character first appears in the Star Trek television series episode "Space Seed" (1967).
  230. Kiran Singh/Solstice. The character first appears in the comic book Teen Titans #89 (2011). She adopts the Solstice identity in Wonder Girl #1 (2011).
  231. Benjamin "Ben" Sisko. The character first appears in the Star Trek: Deep Space Nine television series pilot episode "Emissary" (1993).
  232. Jacob "Jake" Sisko. The character first appears in the Star Trek: Deep Space Nine television series pilot episode "Emissary" (1993). His formal first name is established in the novelization of the episode.
  233. Jennifer DeWitt Sisko. The character first appears in the Star Trek: Deep Space Nine pilot episode "Emissary" (1993). Her maiden name is established in ???
  234. Joseph Sisko. The character first appears in the Star Trek: Deep Space Nine television series episode "Homefront" (1996).
  235. Skeletor/Keldor. The character first appears in mini-comics packaged with He-Man and the Masters of the Universe action figures (1982). His original name of Keldor is firmly connected with a version of the character in the He-Man and the Masters of the Universe animated series premiere episode "The Beginning" (2002).
  236. Jack Skellington. The character first appears in the stop-motion animated feature film The Nightmare Before Christmas (1993).
  237. Skurge the Executioner. The character first appears in the comic book Journey into Mystery #103 (1964).
  238. Ema Skye. The character first appears in the DLC chapter Rise from the Ashes to the internationally released DS version of Phoenix Wright: Ace Attorney (2005).
  239. Anakin Skywalker/Darth Vader. The character technically first appears, as Darth Vader, in the novelization Star Wars: From the Adventures of Luke Skywalker (1976), but more commonly is considered to first appear in the film Star Wars (1977). He is established to be the previously mentioned Anakin Skywalker in the film The Empire Strikes Back (1980).
  240. Ben Skywalker. The character first appears in the Star Wars novel The New Jedi Order: Edge of Victory II: Rebirth (2001).
  241. Luke Skywalker. The character technically first appears in the novelization Star Wars: From the Adventures of Luke Skywalker (1976), but more commonly is considered to first appear in the film Star Wars (1977).
  242. Shmi Skywalker Lars. The character first appears in the film Star Wars Episode I: The Phantom Menace (1999). She is established to have married and taken the Lars name in Star Wars Episode II: Attack of the Clones (2002).
  243. Slash/Spike. The character first appears in the comic book Teenage Mutant Ninja Turtles Adventures #23 (1991).
  244. Albert Clifford "A.C." Slater. The character first appears in the Saved by the Bell television series debut episode "Dancing to the Max" (1989).
  245. Jerry Sledge/Stonewall. The character first appears in the comic book Mighty Avengers #13 (2008).
  246. Sleepy (dwarf). The seven unnamed dwarves first appear in the short story "Snow White" in the anthology Grimm's Fairy Tales (1812). The distinct Sleepy character first appears in the Disney animated film Snow White and the Seven Dwarfs (1937).
  247. K.K. Slider. The character first appears in the video game Animal Forest (2001).
  248. Edward "Slightly" Slight Darling. The character first appears in the stage play Peter Pan; or the Boy Who Wouldn't Grow Up (1904). His real name is established in the novel Peter and the Secret of Rundoon (2006).
  249. Slimer/Willem Remils. The character first appears in the film Ghostbusters (1984). His original surname is established in The Real Ghostbusters comic strip (c. 1988). His original given name is arbitrary.
  250. Mark Sloan (detective physician). The character first appears on the Jake and the Fatman television series episode "It Never Entered My Mind" (1991).
  251. Lily Sloane. The character first appears in the film Star Trek: First Contact (1996).
  252. Slo-bo. The character first appears in the comic book Young Justice #37 (2001).
  253. Slovakia (Tan). The character first appears in the manga Hetalia: Axis Powers Chapter Hetalia World Stars 85 (2015).
  254. William "Will" Smalls. The character first appears, with the Japanese name Itsuki, in the video games Pokémon Gold and Silver Versions (1999). He is given the name Will in the North American release (2000), His full name is arbitrary.
  255. Marrina Smallwood. The character first appears in the comic book Alpha Flight #1 (1983).
  256. Smaug. The character first appears in the novel The Hobbit (1937).
  257. William Smee. The character first appears in the stage play Peter Pan; or the Boy Who Wouldn't Grow Up (1904). His given name is established in the television miniseries Neverland (2011).
  258. Agent Smith (A.I.). The character first appears in the film The Matrix (1999).
  259. Beth Sanchez Smith. The character first appears in the Rick and Morty animated series pilot episode (2013).
  260. Cleopatra Smith. The character first appears in the Clone High animated series premiere episode "Escape to Beer Mountain: A Rope of Sand" (2002). Her surname is established in ???
  261. Denis Nayland Smith. The character first appears in the short story "The Zayat Kiss", published in The Storyteller (1912).
  262. Erwin Smith. The character first appears in the Attack on Titan manga initial chapter "To You, 2000 Years from Now" (2009). His name is established in ???
  263. Guy Smith/The Orphan/Mr. Sensitive. The character first appears in the comic book X-Force #117 (2001).
  264. Harold "Pitfall Harry" Smith. The character first appears in the video game Pitfall! (1982). His full given and surnames are arbitrary.
  265. Harold "Pitfall Harry" Smith Jr. The character first appears in the video game Pitfall: The Mayan Adventure (1994). His full given and surnames are arbitrary.
  266. Jerry Smith. The character first appears in the Rick and Morty animated series pilot episode (2013).
  267. John Hannibal Smith. The character first appears in the The A-Team television series pilot episode "Mexican Slayride" (1983).
  268. Lavinia Smith. The character first appears in the K-9 and Company pilot episode "A Girl's Best Friend" (1981).
  269. Luke Smith. The character first appears in the The Sarah Jane Adventures television series pilot episode "Invasion of the Bane" (2007).
  270. Mickey Smith. The character first appears in the Doctor Who television series episode "Rose" (2005).
  271. Mortimer "Morty" Smith. The character first appears in the Rick and Morty animated series pilot episode (2013).
  272. Neville "Nibs" Smith Darling. The character first appears in the stage play Peter Pan; or the Boy Who Wouldn't Grow Up (1904). His real name is arbitrary.
  273. Sarah Jane Smith. The character first appears in the Doctor Who television series episode "The Time Warrior, Part One" (1973).
  274. Sharon Smith/Catseye. The character first appears in the comic book New Mutants #16 (1984).
  275. Sky Smith. The character first appears in the The Sarah Jane Adventures television series episode "Sky" (2011).
  276. Summer Smith. The character first appears in the Rick and Morty animated series pilot episode (2013).
  277. Tabitha Smith/Boom-Boom/Boomer/Meltdown. The character first appears in the comic book Secret Wars II #5 (1985). Her surname is established in ??? She adopts the Boomer identity in X-Force #16 (1992), and Meltdown in X-Force #51 (1996).
  278. Valerie Smith. The character first appears in the comic book Josie and the Pussycats #45 (1969).
  279. William "Will" Smith (Fresh Prince). The character, a highly fictionalized version of the actor who portrayed him, first appears in the The Fresh Prince of Bel-Air television series pilot episode "The Fresh Prince Project" (1990).
  280. Winston Smith. The character first appears in the novel Nineteen Eighty-Four (1949).
  281. Zachary Smith. The character first appears in the Lost in Space television series premiere episode "The Reluctant Stowaway" (1965).
  282. Agatha Smith-Jones. The character first appears, under her Japanese name Kikuko, in the video games Pokémon Red and Green Versions (1996). She receives the English dub name Agatha in the English release (where Green is now Blue) (1998). Her surname is arbitrary.
  283. Smokey Bear. The character first appears in advertising for the United States Forest Service (1944).
  284. Smurfette Smurf. The character first appears in a Les Schtroumpfs comic strip album, The Smurfette (1966).
  285. Evelyn Smythe Rossiter. The character first appears in the Doctor Who audio drama The Marian Conspiracy (2000). She marries Justice Rossiter and takes his surname in the audio drama Thicker than Water (2005).
  286. Alistair Smythe/Spider-Slayer. The character first appears in the comic book Amazing Spider-Man Annual #19 (1985).
  287. Nash Smythe/The Mist. The character first appears in the comic book Starman #0 (1994).
  288. Spencer Smythe. The character first appears in the comic book Amazing Spider-Man #25 (1965).
  289. Snagglepuss. The character first appears in the The Quick Draw McGraw Show animated series segment "Lamb Chopped" (1959).
  290. Solid Snake/David. The character first appears in the video game Metal Gear (1987).
  291. Snap (Keebler). The character first appears in advertising for Kellogg's Rice Krispies cereal (1933).
  292. Severus Snape. The character first appears in the novel Harry Potter and the Philosopher's Stone (1997).
  293. Leonard Snart/Captain Cold. The character first appears in the comic book Showcase #8 (1957).
  294. Sneezy (dwarf). The seven unnamed dwarves first appear in the short story "Snow White" in the anthology Grimm's Fairy Tales (1812). The distinct Sneezy character first appears in the Disney animated film Snow White and the Seven Dwarfs (1937).
  295. Olive Snook. The character first appears in the Pushing Daisies television series pilot episode "Pie-lette" (2007).
  296. Snoopy. The character first appears in the Peanuts daily comic strip (1950).
  297. Snow White. The character first appears, outside of oral folklore, in the short story "Snow White" in the anthology Grimm's Fairy Tales (1812).
  298. Brian Snow. The character first appears in the film The Warriors (1979). His given name is arbitrary.
  299. Caitlin Snow/Killer Frost. The character first appears in the comic book Fury of Firestorm: The Nuclear Man #19 (2013).
  300. Christmas "Chrissy" Snow. The character first appears in the Three's Company television series pilot episode "Man About the House" (1977).
  301. Cindy Snow. The character first appears in the Three's Company television series episode "Chrissy's Cousin" (1980).
  302. Coriolanus Snow. The character first appears in the novel The Hunger Games (2008).
  303. Aloysius "Snuffy" Snuffleupagus. The character first appears in the Sesame Street television series episode #276 (1971). His given name is established in ???
  304. Luke Snyder/Luciano Grimaldi. The character first appears/is born in an episode of the television series As the World Turns airing in 1995.
  305. Solaire of Astora. The character first appears in the video game Dark Souls (2011).
  306. Soleil (daughter of Inigo). The character first appears in the video game Fire Emblem: If (2015).
  307. Soleta. The character first appears in the Star Trek: The Next Generation novella Starfleet Academy #1: Worf's First Adventure (1993).
  308. Jarem Solim Kaz. The character first appears in the Star Trek: Voyager novel Homecoming (2003). His surname is arbitrary.
  309. Solis/Lightray. The character first appears in the comic book New Gods #1 (1971).
  310. Allana Solo. The character first appears in the Star Wars novel Dark Nest II: The Unseen Queen (2005).
  311. Anakin Solo. The character first appears in the Star Wars novel Dark Apprentice (1994).
  312. Ben Solo/Kylo Ren. The character first appears in the film Star Wars: Episode VII: The Force Awakens (2015).
  313. Han Solo. The character technically first appears in the novelization Star Wars: From the Adventures of Luke Skywalker (1976), but more commonly is considered to first appear in the film Star Wars (1977).
  314. Jacen Solo/Darth Caedus. The character is born in the Star Wars novel The Last Command (1993). He adopts the Sith name Darth Caedus in the novel Legacy of the Force: Sacrifice (2007).
  315. Jaina Solo. The character is born in the Star Wars novel The Last Command (1993).
  316. Soloman/110. The character first appears in the Star Trek: S.C.E. ebook novella The Belly of the Beast (2000). He adopts the new name Soloman in Hard Crash (2000).
  317. Solomon of the United Monarchy. The character apparently first appears in the Second Book of Judges in the Tanakh/Bible, written in antiquity.
  318. Harry Solomon. The character first appears in the 3rd Rock from the Sun television series pilot episode "Brain and Eggs" (1996).
  319. Richard "Dick" Solomon. The character first appears in the 3rd Rock from the Sun television series pilot episode "Brain and Eggs" (1996).
  320. Sally Solomon. The character first appears in the 3rd Rock from the Sun television series pilot episode "Brain and Eggs" (1996).
  321. Tommy Solomon. The character first appears in the 3rd Rock from the Sun television series pilot episode "Brain and Eggs" (1996).
  322. Solomon Grundy/Cyrus Gold. The character first appears in the comic book All-American Comics #61 (1944).
  323. Jaime Sommers/Bionic Woman. The character first appears in the The Six Million Dollar Man television series episode "The Bionic Woman, Part 1" (1975).
  324. Son Joon/Oddjob. The character first appears in the James Bond novel Goldfinger (1959). His real name is arbitrary.
  325. River Song/Melody Pond/Mels. The character first appears, in her third incarnation, in the Doctor Who television series episode "Silence in the Library" (2008). Her first incarnation first appears, unnamed, in "The Impossible Astronaut" (2011). Her first incarnation is born, receiving the name Melody Pond (Williams) in the episode "A Good Man Goes to War" (2011). Her second incarnation, "Mels", first appears in the episode "Let's Kill Hitler" (2011).
  326. Sonia the Hedgehog. The character first appears in the Sonic Underground animated series debut episode "Wedding Bell Blues" (1999).
  327. Sonic the Hedgehog/Maurice Hedgehog. The character first appears in the video game Sonic the Hedgehog (1991). His birth name is established in the Sonic the Hedgehog animated series (1993).
  328. Sonny the Cuckoo Bird. The character first appears in advertising for General Mills' Cocoa Puffs cereal (1962).
  329. Arik Soong. The character first appears in the Star Trek: Enterprise television series episode "Borderland" (2004).
  330. Noonien Soong. The character first appears in the Star Trek: The Next Generation television series episode "Brothers" (1990).
  331. Sophie (daughter of Silas). The character first appears in the video game Fire Emblem: If (2015).
  332. Anthony "Tony" Soprano. The character first appears in the The Sopranos television series pilot episode (1999).
  333. Sora of Destiny. The character first appears in the video game Kingdom Hearts (2002).
  334. Soren (Greil Mercenary). The character first appears, as Senerio, in the video game Fire Emblem: Path of Radiance (2005). The Soren name is established in the Noth American release (2005).
  335. Bridgette Soren. The character first appears in the Total Drama Island animated series premiere episode "Not-So Happy Campers, Part 1" (2007). Her surname is arbitrary.
  336. Asuka Langley Soryu. The character first appears in the Neon Genesis Evangelion anime episode "Asuka Arrives in Japan" (1995).
  337. Lyra Soul. The character first appears in the video games Pokémon HeartGold and SoulSilver Versions (2009). Her English name, Lyra, is established in the North American release (2010). Her surname is arbitrary.
  338. Soundwave (Decepticon). The character first appears in the The Transformers animated series episode "More Than Meets the Eye, Part 1" (1984).
  339. Goldilocks Southey. A character filling her role first appears outside of oral tradition in the short story "The Story of the Three Bears" in the anthology The Doctor (1837). The character becomes a young girl in the anthology A Treasury of Pleasure Books for Young Children (1849), and finally receives the name Goldilocks in Old Nursery Rhymes and Stories (1904). Her surname is arbitrary.
  340. Soval. The character first appears in the Enterprise television series pilot episode "Broken Bow" (2001).
  341. Samuel "Sam" Spade. The character first appears in the novel The Maltese Falcon (1930).
  342. Spain/España (Tan). The character first appears on the Axis Powers: Hetalia manga Volume 1 (2008).
  343. Jessica "Jessie" Spano. The character first appears in the Saved by the Bell television series debut episode "Dancing to the Max" (1989).
  344. Wilson "Sparky" Sparkolomew. The character first appears, as Sabu, in the first chapter of Mach GoGoGo manga published in Shonen Book magazine (1966). His English nickname, Sparky, is established in the Speed Racer anime adaptation's premiere episode "The Great Plan, Episode 1" (1967). His real name is established in the film Speed Racer (2008).
  345. Jodene Sparks. The character first appears in the Sealab 2021 animated series preview episode "Radio Free Sealab" (2000). His surname is established in "Happycake" (2000). His given name is established ???
  346. Jack Sparrow. The character first appears in the film Pirates of the Caribbean: Curse of the Black Pearl (2003).
  347. Roxanne "Roxy" Spaulding/Freefall. The charcter first appears in the comic book Deathmate Black (1994).
  348. Speed Buggy. The character first appears in the Speed Buggy animated series premiere episode "Speed Buggy Went That-a-Way" (1973).
  349. Hildegard "Hilda" Spellman. The character first appears, as "Hilda the Witch", in the comic book Archie's Mad House #19 (1962). She becomes Sabrina's aunt and presumably the Spellman surname in Archie's Mad House #37 (1964). Her full first name is established in ???
  350. Sabrina Spellman. The character first appears in the comic book Archie's Mad House #22 (1962).
  351. Zerelda "Zelda" Spellman. The character first appears in the comic book Archie's Mad House #65 (1968). Her full first name is established in ???
  352. Katherine "Kate" Spencer/Manhunter. The character first appears in the comic book Manhunter #1 (2004).
  353. Mary Anne Spencer Bartokomous. The character first appears in the Perfect Strangers episode "Hunks Like Us" (1986).
  354. Ramsey Robinson Spencer/Manhunter. The character first appears in the comic book Manhunter #4 (2004). He first appears as Manhunter in Manhunter #38 (2009).
  355. Egon Spengler. The character first appears in the film Ghostbusters (1984).
  356. Spike Spiegel. The character first appears in the Cowboy Bebop premiere episode "Asteroid Blues" (1998).
  357. Spike (stegosaurus). The character first appears in the animated feature film The Land Before Time (1988).
  358. Ashley Spinelli. The character first appears in the Recess animated series premiere episode "The Break-In" (1997).
  359. Constance Spivey/Concierge. The character first appears in the The Awesomes animated series pilot episode (2013). Her real name is arbitrary.
  360. Splinter. The character first appears in the comic book Teenage Mutant Ninja Turtles #1 (1984).
  361. Spock. The character first appears in the Star Trek television series episode "The Man Trap" (1966), though he was created for the first pilot episode, "The Cage", which did not air until 1988.
  362. Connie Springer. The character first appears in the Attack on Titan manga chapter "That Day" (2009).
  363. Heidi Springfield/Hyena. The character first appears in the Gargoyles animated series episode "The Thrill of the Hunt" (1994). Her real name is arbitrary.
  364. Jakob Springfield/Jackal. The character first appears in the Gargoyles animated series episode "The Thrill of the Hunt" (1994). His real name is arbitrary.
  365. Elmo Sputterspark/Megavolt. The character first appears in the Darkwing Duck animated series episode "Duck Blind" (1991).
  366. Spyro the Dragon. The character first appears in the video game Spyro the Dragon (1998).
  367. Spongebob Squarepants. The character first appears in the Spongebob Squarepants animated series premiere episode "Help Wanted" (1999).
  368. Andrew "Squiggy" Squiggman. The character first appears, outside live comedy routines, in the Laverne DeFazio & Shirley Feeney television series pilot episode "The Society Party" (1976).
  369. Conker The Squirrel. The character first appears in the video game Diddy Kong Racing (1997).
  370. Rocket "Rocky" Squirrel. The character first appears in the Rocky & His Friends animated series premiere episode "Jet Fuel Formula" (1959).
  371. Scaredy Squirrel. The character first appears in the children's book Scaredy Squirrel (2006).
  372. Secret Squirrel. The character first appears in the animated broadcast television special The World of Atom Ant and Secret Squirrel (1965).
  373. Skippy Squirrel. The character first appears in the Animaniacs animated series episode segment "The Monkey Song" (1993).
  374. Slappy Squirrel. The character first appears in the Animaniacs animated series episode segment "The Monkey Song" (1993).
  375. Red's Squirtle. The character first appears, unnamed, in the Pokémon anime episode "Enter the [Squirtle] Squad!" (1997).
  376. Squit. The character first appears in the Animaniacs animated series episode segment "The Monkey Song" (1993).
  377. Ssard. The character first appears in the Doctor Who comic strip story "Descendance", printed in Radio Times magazine (1996).
  378. Claudette St. Croix/M/Monet St. Croix/Penance. The character first appears, as part of "Monet St. Croix" in Uncanny X-Men #316 (1994). She is revealed as Claudette in Generation X #31 (1997).
  379. Marius St. Croix/Emplate. The character first appears in the comic book Generation X #1 (1994).
  380. Monet St. Croix/M/Penance. The character first appears, as part of Penance, in Generation X #1 (1994). She is freed from Penance and adopts the M identity in Generation X #40 (1998).
  381. Nicole St. Croix/M/Monet St. Croix/Penance. The character first appears, as part of "Monet St. Croix" in Uncanny X-Men #316 (1994). She is revealed as Nicole in Generation X #31 (1997).
  382. Elliot Stabler. The character first appears in the Law & Order: Special Victims Unit television series premiere episode "Payback" (1999).
  383. Sookie Stackhouse. The character first appears in the debut True Blood novel Dead Until Dark (2001).
  384. Gabriel Stacy/Grey Goblin. The character first appears in the comic book The Amazing Spider-Man #509 (2004).
  385. George Stacy. The character first appears in the comic book The Amazing Spider-Man #56 (1968).
  386. Gwendolyn "Gwen" Stacy. The character first appears in the comic book The Amazing Spider-Man #31 (1965).
  387. Sarah Stacy. The character first appears in the comic book The Amazing Spider-Man #509 (2004).
  388. Stahl of Ylisse. The character first appears, as Sort, in the video game Fire Emblem: Awakening (2012). He receives the Stahl name in the English release (2013).
  389. Paul Stamets. The character first appears in the Star Trek: Discovery television series premiere episode "The Vulcan Hello" (2017).
  390. Claire Standish. The character first appears in the film The Breakfast Club (1985).
  391. Jenna Stannis. The character first appears in the Blake's 7 pilot episode "The Way Back" (1978).
  392. Raymond "Ray" Stantz. The character first appears in the film Ghostbusters (1984).
  393. Patrick Star. The character first appears in the Spongebob Squarepants animated series premiere episode "Help Wanted" (1999).
  394. Yuriko Star. The character first appears in the The Most Irresponsible Man in Space light novel The Irresponsible Captain Tylor (1989).
  395. Starfy. The character first appears in the video game The Legendary [Starfy] (2002). His English name is established in the North American release of another game, The Legendary Starfy (2009).
  396. Anthony "Tony" Stark/Iron Man. The character first appears in the comic book Tales of Suspense #39 (1963).
  397. Anthony "Tony" Stark (teen). The character first appears in the comic book Avengers: Timeslide (1996).
  398. Arno Stark/Iron Man. The character first appears in the comic book Machine Man #2 (1984).
  399. Jim Stark. The character first appears in the film Rebel without a Cause (1955).
  400. Misty's Starmie. The character first appears, unnamed, in the video games Pokémon Red and Green Versions (1996).
  401. Lone Starr. The character first appears in the film Spaceballs (1987).
  402. Starscream. The character first appears in the The Transformers animated series episode "More Than Meets the Eye, Part 1" (1984).
  403. Jonothon "Jono" Starsmore/Chamber. The character first appears in the comic book Generation X #1 (1994).
  404. Misty's Staryu. The character first appears in the video games Pokémon Red and Green Versions (1996).
  405. S'task. The character first appears in the Star Trek novel The Romulan Way (1987).
  406. Jennifer Stavros/Roulette. The character first appears in the comic book New Mutants #16 (1984).
  407. Stealth (Gryxian). The character first appears in the comic book L.E.G.I.O.N. '89 #1 (1989).
  408. Anastasia Steele. The character first appears in the novel Fifty Shades of Grey (2011).
  409. Cliff Steele/Robotman. The character first appears in the comic book My Greatest Adventure #80 (1963).
  410. Chase Stein/Talkback. The character first appears in the comic book Runaways #1 (2003).
  411. Janet Ever Stein. The character first appears in the comic book Runaways #1 (2003). Her maiden name is arbitrary.
  412. Martin Stein/Firestorm. The character first appears in the comic book Firestorm #1 (1978).
  413. Victor Stein. The character first appears in the comic book Runaways #1 (2003).
  414. Geo Stelar/Mega Man. The character first appears in the video games Mega Man Star Force Pegasus, Leo, and Dragon (2006).
  415. Adam Stephens. The character first appears in the Bewitched television series episode "…And Something Makes Four" (1969). He is named in the episode "Naming Samantha's New Baby" (1969).
  416. Darrin Stephens. The character first appears in the Bewitched television series pilot episode "I, Darrin, Take This Witch, Samantha" (1964).
  417. Samantha "Sam" Stephens. The character first appears in the Bewitched television series pilot episode "I, Darrin, Take This Witch, Samantha" (1964).
  418. Tabitha Stephens. The character first appears in the Bewitched television series episode "And Then There Were Three" (1966).
  419. Ivan Steranko/Rocksteady. The character first appears in "Turtle Tracks", the premiere episode of the animated series Teenage Mutant Ninja Turtles (1987). His real name is established in the episode "Enemy of My Enemy" of a later animated series also titled Teenage Mutant Ninja Turtles (2013).
  420. Lilith Sternin/Sternin-Crane. The character first appears in the Cheers television series episode "Second Time Around" (1986).
  421. Fabian Stevens. The character first appears in the Star Trek: Deep Space Nine television series episode "Starship Down" (1995). His given name is established in the Star Trek: S.C.E. ebook novella The Belly of the Beast (2000).
  422. John Stewart/Green Lantern/Darkstar. The character first appears in the comic book Green Lantern #87 (1971).
  423. Miley Stewart/Hannah Montana. The character first appears in the Hannah Montana television series premiere episode "Lilly, Do You Want to Know a Secret?" (2006).
  424. Troy Stewart/Cacophony. The character first appears in the comic book Superboy #216 (1976). The later code-name of Cacophony is apocryphal.
  425. Sticks the Badger. The character, though created for the video game Sonic Boom: Rise of Lyric (2014), she first appears in the comic book Sonic Boom #1 (2014).
  426. Stitch/Experiment 626. The character first appears in the film Lilo & Stitch (2002).
  427. Baxter Stockman. The character first appears in the comic book Teenage Mutant Ninja Turtles #2 (1984).
  428. Stompa. The character first appears in the comic book Mister Miracle #6 (1972).
  429. Jeremy Stone/Maul. The character first appears in the comic book WildC.A.T.s #1 (1992).
  430. Steven Stone. The character first appears, with his Japanese name of Daigo Tsuwabuki, in the video games Pokémon Ruby and Sapphire Versions (2002). His dub name Steven Stone is established in the English release (2003).
  431. Victor "Vic" Stone/Cyborg. The character first appears in the comic book DC Comics Presents #26 (1980).
  432. Ronald "Ron" Stoppable. The character first appears in the Kim Possible animated series premiere episode "Crush" (2002).
  433. Jonathan "Johnny" Storm/Human Torch. The character first appears in the comic book Fantastic Four #1 (1961). His proper given name is established in ???
  434. Susan "Sue" Storm Richards/Invisible Woman/Invisible Girl/Malice. The character first appears in the comic book Fantastic Four #1 (1961). She changes her name to Richards upon marrying in Fantastic Four Annual #3 (1965). She adopts the Invisible Woman code-name in Fantastic Four #284 (1985).
  435. Torus Storm/Super-Storm. The character first appears in the comic book Fantastic Five #2 (1999).
  436. Adam Strange. The character first appears in the comic book Showcase #17 (1958).
  437. Alanna Strange. The character first appears in the comic book Showcase #17 (1958). She takes the Strange surname upon marrying Adam in ???
  438. Aleea Strange. The character first appears (is born in) in the comic book Adam Strange #3 (1990).
  439. Stephen Strange/Doctor Strange. The character first appears in the comic book Strange Tales #110 (1963).
  440. Strangelove. The character first appears in the film Dr. Strangelove or: How I Learned to Stop Worrying and Love the Bomb (1964).
  441. Strata. The character first appears in the comic book Invasion! #2 (1989).
  442. Miles Chang Straume. The character first appears in the Lost television series episode "Confirmed Dead" (2008). His birth surname is established in ???
  443. Thomas "Tommy" Strawn. The character first appears in the Martin television series pilot episode "Beauty and the Beast" (1992).
  444. Strax. The character first appears in the Doctor Who television series episode "A Good Man Goes to War" (2011).
  445. Streaky the Super-Cat. The character first appears in the comic book Action Comics #261 (1960).
  446. Della Street. The character first appears in the Perry Mason novel The Case of the Velvet Claws (1933).
  447. Cloud Strife. The character first appears in the video game Final Fantasy VII (1997).
  448. Strika. The character first appears in the Beast Machines: Transformers animated series episode "The Strike" (2000).
  449. Ted Striker. The character first appears, as Ted Stryker, in the film Zero Hour! (1957). The Striker version first appears in the film Airplane! (1980).
  450. Harry Strong III/Muscleman. The character first appears in the The Awesomes animated series pilot episode (2013).
  451. Strong Bad. The character first appears in the children's book The Homestar Runner (1996).
  452. Stryfe. The character first appears in the comic book New Mutants #86 (1990).
  453. William Stryker. The character first appears in the comic book Marvel Graphic Novel #5 (1983).
  454. Alistaire Stuart. The character first appears in the comic book Excalibur #6 (1989).
  455. Alysande Stuart. The character first appears in the comic book Excalibur #6 (1989).
  456. Jake Styles. The character first appears in the Jake and the Fatman television series debut episode "Happy Days Are Here Again" (1987).
  457. Sadie Su. The character first appears in the Total Drama Island animated series premiere episode "Not-So Happy Campers, Part 1" (2007). Her surname is arbitrary.
  458. Subaki of Hoshido. The character first appears in the video game Fire Emblem: If (2015).
  459. Sue (ghost). The character first appears in the arcade game Ms. Pac-Man (1982).
  460. Sue (daughter of Rath). The character first appears in the video game Fire Emblem: The Binding Blade (2002).
  461. Suibhne/Mad Sweeney. The character first appears in the Irish tale Buile Suibhne (c. 1100).
  462. Suicune. The character first appears in the video games Pokémon Gold and Silver Versions (1999).
  463. Ming Sul/Amp Girl. The character first appears in the comic book The Legion #25 (2003).
  464. Austin Sullivan/Impresario. The character first appears in the The Awesomes animated series pilot episode (2013). His real name is established in ???
  465. Chloe Sullivan. The character first appears in the Smallville television series pilot episode (2001).
  466. Harry Sullivan. The character first appears in the Doctor Who television series episode "Robot, Part One" (1974).
  467. Sully of Ylisse. The character first appears in the video game Fire Emblem: Awakening, as Soiree. She received the English name Sully in the North American release (2013).
  468. Demora Ling Sulu. The character first appears in the film Star Trek: Generations (1994). Her birth surname is established in the Star Trek novel The Captain's Daughter (1995).
  469. Hikaru Sulu. The character first appears in the Star Trek television series premiere episode "The Man Trap" (1966). His given name is established in the Star Trek novel The Entropy Effect (1981).
  470. Sumia of Ylisse. The character first appears in the video game Fire Emblem: Awakening (2012).
  471. Jody Summer. The character first appears in the video game F-Zero X (1998).
  472. Bernice "Benny" Summerfield. The character first appears in the Doctor Who: The New Adventures novel Love and War (1992).
  473. Peter Summerfield. The character first appears in the Bernice Summerfield novel The Glass Prison (2002).
  474. Alexander "Alex" Summers/Havok. The character first appears in the comic book X-Men #54 (1969). He adopts the Havok code-name in X-Men #58 (1969).
  475. Buffy Summers. The character first appears in the film Buffy the Vampire Slayer (1992). Her surname is established in the Buffy the Vampire Slayer television series pilot episode "Welcome to Hellmouth" (1997).
  476. Dawn Summers. The character first appears in the Buffy the Vampire Slayer television series episode "Buffy vs. Dracula" (2000).
  477. Gabriel Summers/Kid Vulcan/Vulcan. The character first appears in the comic book X-Men: Deadly Genesis #1 (2006).
  478. Mary Ann Summers. The character first appears in the Gilligan's Island television series premiere episode "Two on a Raft" (1964).
  479. Nathaniel Christopher "Nathan"/"Nate" Summers/Nathan Dayspring/Askani'Son/Cable. The character first appears, unnamed, in the comic book Uncanny X-Men #201 (1986). His birth name is established in Uncanny X-Men #239 (1989). He first appears as Cable in New Mutants #86 (1990). His Dayspring adopted surname is established in ???, and the Askani'Son referent in ???
  480. Rachel Summers/Marvel Girl/Phoenix/Prestige. The character first appears in the comic book X-Men #141 (1981). Her surname is established in Uncanny X-Men #188 (1985). She adopts the Phoenix code-name in Uncanny X-Men #199 (1985), Marvel Girl in X-Treme X-Men #46 (2004), and Prestige in X-Men: Gold #1 (2017).
  481. Ruby Summers. The character first appears in the comic book X-Factor: Layla Miller #1 (2008).
  482. Scott "Slim" Summers/Cyclops. The character first appears in the comic book X-Men #1. His given name is established in X-Men #3 (1964).
  483. Sunni Gummi. The character first appears in the Disney's Adventures of the Gummi Bears animated series premiere episode "A New Beginning" (1985).
  484. Sunshine (Goldeen). The character first appears in the Pokémon anime episode "Showdown! Pokémon Center!" (1997). Its name is apocryphal.
  485. Supreme Intelligence. The character first appears in the comic book Fantastic Four #65 (1967).
  486. Abin Sur/Green Lantern. The character first appears in the comic book Showcase #22 (1959).
  487. Surak. The character first appears in the Star Trek novel Spock's World (1989).
  488. Daniel Surge. The character first appears, under his Japanese name Matis, in the video games Pokémon Red and Green Versions (1996). He receives the English dub name Lt. Surge in the English release (where Green is now Blue) (1998). His given name is arbitrary.
  489. Susan Foreman Campbell. The character first appears in the Doctor Who television series pilot episode "An Unearthly Child" (1963).
  490. Roxanne Sutton/Roxy Rocket. The character first appears in the comic book Batman Adventures Annual #1 (1994).
  491. Toji Suzuhara/Fourth Child. The character first appears in the Neon Genesis Evangelion anime series episode "The Phone that Never Rings" (1995).
  492. Swamp Thing. The character first appears in the comic book Swamp Thing #1 (1972).
  493. Emma Swan. The character first appears in the Once Upon a Time television series pilot episode (2011).
  494. Isabella "Bella" Swan. The character first appears in the novel Twilight (2005).
  495. Michael Swan. The character first appears in the film The Warriors (1979). His given name is arbitrary.
  496. Elizabeth Swann. The character first appears in the film Pirates of the Caribbean: Curse of the Black Pearl (2003).
  497. Katherine "Katie" Sweet. The character first appears in the Total Drama Island animated series premiere episode "Not-So Happy Campers, Part 1" (2007). Her full name is arbitrary.
  498. Richard Swift/Shade the Immortal. The character first appears in the comic book Flash Comics #33 (1942).
  499. Carl "Alfalfa" Switzer. The character first appears is the Our Gang short film Beginner's Luck (1935). He is identified as Alfalfa in the short film Teacher's Beau (1935). His real name is based on the actor who played him.
  500. Beverly Switzler. The character first appears in the comic book Howard the Duck #1 (1976).
  501. Sybok. The character first appears in the film Star Trek V: The Final Frontier (1989).
  502. Augustine Sycamore. The character first appears in the video games Pokémon X and Y Versions (2013).
  503. Fred Sykes/Fang. The character first appears in the Gargoyles animated series episode "Metamorphosis" (1995). His real name is established in ???
  504. S'ym. The character first appears in the comic book Uncanny X-Men #160 (1982).
  505. Brown Syrup. The character first appears in the video game Wario Land: Super Mario Land 3 (1994).
  506. Aleksei Sytsevich/Rhino/Alex O'Hirn. The character first appears in the comic book The Amazing Spider-Man #41 (1966). His birth name is established ??
  507. Syzoth/Reptile. The character first appears in the arcade video game Mortal Kombat (1992). His real name is established in Mortal Kombat X (2015).
  508. Margali Szardos. The character first appears in the comic book X-Men Annual #4 (1980).
  509. Morris "Moe" Szyslak. The character first appears in the The Simpsons animated series first episode "Simpsons Roasting on an Open Fire" (1989). His surname is established in the episode "Who Shot Mr. Burns? (Part One)" (1995).
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